2021 Meeting - Virtual


Bio-Ontologies will be in its 24th year at ISMB 2021 which will be held as an ONLINE CONFERENCE between July 25-29, 2021. Bio-ontologies strives to provide a vibrant environment for reporting novel methods and sharing experiences on the construction and application of ontologies in health care and the life sciences.

The COSI offers a constructive environment to nurture discussion of innovative and scientifically sound work that ranges from preliminary to completed, from both young and experienced investigators alike. Bio-Ontologies participants also benefit from a strongly interdisciplinary setting, where ISMB attendees intermingle with members from American Medical Informatics Association (AMIA) and the W3C’s Healthcare and Life Sciences Community Group (HCLSCG), thereby increasing impact through broader dissemination and enabling new and exceptional collaborations. This year's event will be integrated into the main conference and will feature papers accepted for the ISMB proceedings.

Access 2021 Presenter Content on our Zenodo Community Page!


2021 Keynote Speakers

Actionable Machine Learning for Drug Discovery and Development

Marinka Zitnik, Harvard University


The success of machine learning depends heavily on the choice of features on which the algorithms are applied. For that reason, much of the efforts go into the engineering of informative features. In this talk, I describe our research in learning deep representations that are actionable and allow endpoint users to ask what-if questions and receive robust predictions that can be interpreted meaningfully. These methods specify deep graph neural functions that can flexibly embed data points into an embedding space, optimized to reflect the topology of input data. Our recent theoretical results allow us to augment the embeddings and make them robust and counterfactually fair. I will describe how these methods enabled the repurposing of drugs for an emerging pathogen and led to downstream validation in human cells. Last, I will highlight Therapeutics Data Commons (https://tdcommons.ai), a platform with AI/ML-ready datasets and tasks for therapeutics together with an ecosystem of tools, libraries, leaderboards, and community resources.


Marinka Zitnik is an Assistant Professor at Harvard University with appointments in the Department of Biomedical Informatics, Broad Institute of MIT and Harvard, and Harvard Data Science. Dr. Zitnik's research is at the interface of machine learning and biomedical informatics, focusing on graph representation learning, knowledge graphs, data fusion, and their applications to network biology and therapeutics. Dr. Zitnik has published extensively in top ML venues and leading interdisciplinary journals. She has organized numerous workshops and tutorials in the nexus of AI, deep learning, drug discovery, and medical AI at leading conferences, where she is also in the organizing committees. Her research won numerous best paper and research awards from the International Society for Computational Biology, Bayer Early Excellence in Science Award, a Rising Star Award in Electrical Engineering and Computer Science, and a Next Generation Award in Biomedicine. 

Aligning Human and Machine Intelligence

Matthias Samwald, University of Vienna


Recent years were marked by outstanding advances in the capabilities of artificial intelligence (AI). Deep learning enabled rapid progress on many benchmarks that were previously deemed difficult to tackle for machine learning algorithms, often achieving human-level performance. Models such as GPT-3 demonstrated problem-solving capabilities across a wide range of intelligence tasks.  Given these developments, AI holds the potential to radically transform society through accelerating technological, biomedical, and societal knowledge creation and innovation. The realization of this potential increasingly hinges on our understanding of how to best define, train, measure, interconnect and utilize AI capabilities. The development of a shared ontology of AI tasks and capabilities is instrumental towards achieving such an understanding. In this talk, I will present recent work on the Intelligence Task Ontology, a large-scale ontology with broad coverage of artificial intelligence tasks, benchmarks, and datasets. I will demonstrate how such ontological models can form the foundation for harnessing AI in biomedical research and clinical decision-making.


Matthias Samwald is an associate professor for biomedical informatics and artificial intelligence at the Medical University of Vienna.  His work is focused on speeding up scientific progress and the development of novel, personalized therapies through advanced AI technologies and knowledge-based systems. He co-authored over 100 peer-reviewed publications in the areas of personalized medicine, NLP, graph machine learning, information retrieval, biomedical ontologies, and clinical decision support systems.

Submission Information

Call for Submissions:  DEADLINE  Thursday, May 6, 2021 (Key Dates as per ISMB

We invite the submission of 1-page poster abstracts, and 2-4 page short papers for oral presentation.  Please prepare your submission using the templates at the bottom of the site. Topics include but not limited to:

Submissions can be made on the ISMB site (Click button below). All submissions accepted for oral presentation can optionally also be presented as a poster. Accepted submissions require that one author register for the conference and present the work. The presenter should identify themselves as the corresponding author during the submission process. The presentations are normally allocated between 10-20 minutes. 

🧐 Review Criteria

All submissions to Bio-Ontologies are reviewed. Review criteria include :

Submission Templates

Template 1


Template 2


2021 Program

2021 Bio-Ontologies Committee

Session Chairs

Journal of Biomedical Semantics - Special Issue!

On behalf of the Bio-Ontologies Community of Special Interest (COSI), we are delighted to announce the incredible opportunity the Journal of Biomedical Semantics (JBMS) brings to our community. With this, we kindly invite you to submit a journal version of your contribution at ISMB/ECCB 2021 Bio-Ontologies to a Special Issue in JBMS

See submissions from prior years here: https://www.biomedcentral.com/collections/sig.